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BDBM345747 5-[6-Benzylamino-2-(2-fluoro-6- methyl-phenoxy)-pyrimidin-4-yl]-1- methyl-1H-pyridin-2-one::US10202360, Example 292

SMILES: Cc1cccc(F)c1Oc1nc(NCc2ccccc2)cc(n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=KKKALFQNCIQLNY-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345747   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345747
PNG
(5-[6-Benzylamino-2-(2-fluoro-6- methyl-phenoxy)-py...)
Show SMILES Cc1cccc(F)c1Oc1nc(NCc2ccccc2)cc(n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C24H21FN4O2/c1-16-7-6-10-19(25)23(16)31-24-27-20(18-11-12-22(30)29(2)15-18)13-21(28-24)26-14-17-8-4-3-5-9-17/h3-13,15H,14H2,1-2H3,(H,26,27,28)
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair