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BDBM345762 (R)-5-[2-(2-Fluoro-6-methyl- phenoxy)-6-(1,2,3,4-tetrahydro- naphthalen-1-ylamino)-pyrimidin-4- yl]-1-methyl-1H-pyridin-2-one::US10202360, Example 307

SMILES: Cc1cccc(F)c1Oc1nc(N[C@@H]2CCCc3ccccc23)cc(n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=GOILPEPQTUKABY-JOCHJYFZSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345762   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345762
PNG
((R)-5-[2-(2-Fluoro-6-methyl- phenoxy)-6-(1,2,3,4-t...)
Show SMILES Cc1cccc(F)c1Oc1nc(N[C@@H]2CCCc3ccccc23)cc(n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C27H25FN4O2/c1-17-7-5-11-21(28)26(17)34-27-30-23(19-13-14-25(33)32(2)16-19)15-24(31-27)29-22-12-6-9-18-8-3-4-10-20(18)22/h3-5,7-8,10-11,13-16,22H,6,9,12H2,1-2H3,(H,29,30,31)/t22-/m1/s1
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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair