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BDBM345767 5-[6-Butylamino-2-(2-chloro-6- methyl-phenoxy)-pyrimidin-4-yl]-1- methyl-1H-pyridin-2-one::US10202360, Example 312

SMILES: CCCCNc1cc(nc(Oc2c(C)cccc2Cl)n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=NPDJZNXHKBVRKG-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345767   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345767
PNG
(5-[6-Butylamino-2-(2-chloro-6- methyl-phenoxy)-pyr...)
Show SMILES CCCCNc1cc(nc(Oc2c(C)cccc2Cl)n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C21H23ClN4O2/c1-4-5-11-23-18-12-17(15-9-10-19(27)26(3)13-15)24-21(25-18)28-20-14(2)7-6-8-16(20)22/h6-10,12-13H,4-5,11H2,1-3H3,(H,23,24,25)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair