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BDBM345769 (S)-5-[2-(2-Chloro-6-methyl- phenoxy)-6-(1-methyl-butylamino)- pyrimidin-4-yl]-1-methyl-1H- pyridin-2-one::US10202360, Example 314

SMILES: CCC[C@H](C)Nc1cc(nc(Oc2c(C)cccc2Cl)n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=UEISZMZLLIHIRO-HNNXBMFYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345769   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345769
PNG
((S)-5-[2-(2-Chloro-6-methyl- phenoxy)-6-(1-methyl-...)
Show SMILES CCC[C@H](C)Nc1cc(nc(Oc2c(C)cccc2Cl)n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C22H25ClN4O2/c1-5-7-15(3)24-19-12-18(16-10-11-20(28)27(4)13-16)25-22(26-19)29-21-14(2)8-6-9-17(21)23/h6,8-13,15H,5,7H2,1-4H3,(H,24,25,26)/t15-/m0/s1
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair