BindingDB logo
myBDB logout

BDBM345799 N-(2-(2,4-difluoro-6- methylphenoxy)-6-(1-methyl-6-oxo- 1,6-dihydropyridin-3-yl)pyrimidin- 4-yl)propane-1-sulfonamide::US10202360, Example 344

SMILES: CCCS(=O)(=O)Nc1cc(nc(Oc2c(C)cc(F)cc2F)n1)-c1ccc(=O)n(C)c1

InChI Key: InChIKey=TUBXORYMDVRFHB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345799   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CREB-binding protein


(Homo sapiens (Human))
BDBM345799
PNG
(N-(2-(2,4-difluoro-6- methylphenoxy)-6-(1-methyl-6...)
Show SMILES CCCS(=O)(=O)Nc1cc(nc(Oc2c(C)cc(F)cc2F)n1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C20H20F2N4O4S/c1-4-7-31(28,29)25-17-10-16(13-5-6-18(27)26(3)11-13)23-20(24-17)30-19-12(2)8-14(21)9-15(19)22/h5-6,8-11H,4,7H2,1-3H3,(H,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



CELGENE QUANTICEL RESEARCH, INC.

US Patent


Assay Description
Determination of the IC50 for the CREBBP inhibitors disclosed herein was performed as follows: CREBBP was cloned and expressed in E. Coli as His-tag ...


US Patent US10202360 (2019)

More data for this
Ligand-Target Pair