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BDBM346073 4-{2-[2-(3- Difluoromethyl- phenyl)-1,6- dimethyl-1H- benzoimidazol-5- ylamino]-thiazol-4- yl}-benzonitrile::US10202370, Example 111

SMILES: Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(F)F

InChI Key: InChIKey=VHGMIVYMEMQVPX-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346073   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346073
PNG
(4-{2-[2-(3- Difluoromethyl- phenyl)-1,6- dimethyl-...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(F)F
Show InChI InChI=1S/C26H19F2N5S/c1-15-10-23-21(30-25(33(23)2)19-5-3-4-18(11-19)24(27)28)12-20(15)31-26-32-22(14-34-26)17-8-6-16(13-29)7-9-17/h3-12,14,24H,1-2H3,(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)

More data for this
Ligand-Target Pair