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BDBM346098 4-{2-[2-(3-tert-Butyl- phenyl)-1,6- dimethyl-1H- benzoimidazol-5- ylamino]-thiazol-4- yl}-benzonitrile::US10202370, Example 144

SMILES: Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(C)(C)C

InChI Key: InChIKey=FWWSUAHDGWATAI-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346098   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346098
PNG
(4-{2-[2-(3-tert-Butyl- phenyl)-1,6- dimethyl-1H- b...)
Show SMILES Cc1cc2n(C)c(nc2cc1Nc1nc(cs1)-c1ccc(cc1)C#N)-c1cccc(c1)C(C)(C)C
Show InChI InChI=1S/C29H27N5S/c1-18-13-26-24(31-27(34(26)5)21-7-6-8-22(14-21)29(2,3)4)15-23(18)32-28-33-25(17-35-28)20-11-9-19(16-30)10-12-20/h6-15,17H,1-5H3,(H,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)

More data for this
Ligand-Target Pair