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BDBM346105 US10202370, Example 151::[2-(3-Isopropyl- phenyl)-1,6- dimethyl-1H- benzoimidazol-5-yl]- (4-pyridin-4-yl- thiazol-2-yl)-amine

SMILES: CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccncc3)c(C)cc2n1C

InChI Key: InChIKey=DFCVBNFAXUROMK-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346105   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM346105
PNG
(US10202370, Example 151 | [2-(3-Isopropyl- phenyl)...)
Show SMILES CC(C)c1cccc(c1)-c1nc2cc(Nc3nc(cs3)-c3ccncc3)c(C)cc2n1C
Show InChI InChI=1S/C26H25N5S/c1-16(2)19-6-5-7-20(13-19)25-28-22-14-21(17(3)12-24(22)31(25)4)29-26-30-23(15-32-26)18-8-10-27-11-9-18/h5-16H,1-4H3,(H,29,30)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a<1.00E+3n/an/an/an/a



AB SCIENCE

US Patent


Assay Description
Colorimetric cell proliferation and viability assay (reagent CellTiter-Blue purchased from Promega cat NG8081) was performed on BaF3 Kit WT cell lin...


US Patent US10202370 (2019)

More data for this
Ligand-Target Pair