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BDBM346206 US10202373, Compound I-18::US10202373, Example 3P

SMILES: CN(C)c1ncc(-c2ccnc(NC(C)=O)c2)c2ccn(c12)S(=O)(=O)C1CC1

InChI Key: InChIKey=ZMAANXFHAPUPBO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346206   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346206
PNG
(US10202373, Compound I-18 | US10202373, Example 3P)
Show SMILES CN(C)c1ncc(-c2ccnc(NC(C)=O)c2)c2ccn(c12)S(=O)(=O)C1CC1
Show InChI InChI=1S/C19H21N5O3S/c1-12(25)22-17-10-13(6-8-20-17)16-11-21-19(23(2)3)18-15(16)7-9-24(18)28(26,27)14-4-5-14/h6-11,14H,4-5H2,1-3H3,(H,20,22,25)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair