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BDBM346221 US10202373, Compound I-35::US10202373, Example 11

SMILES: Cc1ncc(-c2ccnc(NC(=O)C3CC3(F)F)c2)c2ccn(c12)S(C)(=O)=O

InChI Key: InChIKey=QQLMTDWOLFLYSJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346221   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346221
PNG
(US10202373, Compound I-35 | US10202373, Example 11)
Show SMILES Cc1ncc(-c2ccnc(NC(=O)C3CC3(F)F)c2)c2ccn(c12)S(C)(=O)=O
Show InChI InChI=1S/C18H16F2N4O3S/c1-10-16-12(4-6-24(16)28(2,26)27)13(9-22-10)11-3-5-21-15(7-11)23-17(25)14-8-18(14,19)20/h3-7,9,14H,8H2,1-2H3,(H,21,23,25)
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair