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BDBM346233 US10202373, Compound I-47::US10202373, Example 10

SMILES: CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccccc1

InChI Key: InChIKey=BJBFWIHGZVMPHT-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 346233   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 3-kinase catalytic subunit type 3


(Homo sapiens (Human))
BDBM346233
PNG
(US10202373, Compound I-47 | US10202373, Example 10)
Show SMILES CCOC(=O)Nc1cc(ccn1)-c1cnc(C)c2n(ccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C22H20N4O4S/c1-3-30-22(27)25-20-13-16(9-11-23-20)19-14-24-15(2)21-18(19)10-12-26(21)31(28,29)17-7-5-4-6-8-17/h4-14H,3H2,1-2H3,(H,23,25,27)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 30n/an/an/an/an/an/a



MILLENNIUM PHARMACEUTICALS, INC.

US Patent


Assay Description
100 nL compounds in DMSO are added to wells of a 384 well microtitre plate (Greiner 780076). At room temperature: 5 ul VPS34 reaction buffer (Invitro...


US Patent US10202373 (2019)

More data for this
Ligand-Target Pair