BDBM347659 2-[2-[2-methoxy-4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl]ethynyl]-6-methylpyridine::US9790203, Example 32

SMILES COc1cc(ccc1C#Cc1cccc(C)n1)-c1nn(C)cc1-c1ccncc1

InChI Key InChIKey=VMLCBKKFIWPXDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 347659   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM347659(2-[2-[2-methoxy-4-[1-methyl-4-(4-pyridyl)pyrazol-3...)
Affinity DataIC50: <100nMAssay Description:Inhibition of recombinant PDE10A (unknown origin) using cAMP/cGMP as substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM347659(2-[2-[2-methoxy-4-[1-methyl-4-(4-pyridyl)pyrazol-3...)
Affinity DataIC50: <100nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent