BDBM349275 (4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4,9-dimethyl-1,3,4,5-tetrahydro-1,5-benzodiazepin-2-one::US10206931, Example 82

SMILES CNc1ccc(cc1C(=N)C1CC1)-c1ccc(C)c2NC(=O)C[C@@H](C)Nc12

InChI Key InChIKey=LAJSFXKVIQBXCH-CYBMUJFWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349275   

TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM349275((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4,9-d...)
Affinity DataIC50:  3.65E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM349275((4R)-6-(3-cyclopropyl-1-methyl-indazol-5-yl)-4,9-d...)
Affinity DataIC50:  99nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent