BDBM349561 US10207991, Ex. Cpd. No. 79::US10611728, Example Compound 79::US11691947, Example 79

SMILES COc1cc(CCC(C)(C)N2Cc3cccc(C(=O)NCCO)c3C2)ccc1O

InChI Key InChIKey=JNUAKGPTMPMPKV-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 349561   

TargetSigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  460nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Rattus norvegicus (Rat))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  460nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  460nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  460nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  1.00E+4nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  1.00E+4nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  1.00E+4nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataKi:  1.00E+4nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cognition Therapeutics

US Patent
LigandPNGBDBM349561(US10207991, Ex. Cpd. No. 79 | US10611728, Example ...)
Affinity DataIC50:  1.10E+4nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent