BDBM349639 2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)-2-(4-(trifluoromethoxy)phenypacetonitrile::US10208016, Compound of Example 9::US10335402, Example 9

SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(C#N)c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=KRQZAVUNAGZXQM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349639   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349639(2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piper...)
Affinity DataIC50:  150nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349639(2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piper...)
Affinity DataIC50:  150nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349639(2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piper...)
Affinity DataIC50:  150nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent