BDBM349649 4-((3,4-Dichlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidine::US10208016, Compound of Example 19::US10335402, Example 19

SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(F)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=GYDNBJRNRTVGET-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349649   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349649(4-((3,4-Dichlorophenyl)fluoromethylene)-1-((3,5-di...)
Affinity DataIC50:  520nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349649(4-((3,4-Dichlorophenyl)fluoromethylene)-1-((3,5-di...)
Affinity DataIC50:  520nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349649(4-((3,4-Dichlorophenyl)fluoromethylene)-1-((3,5-di...)
Affinity DataIC50:  520nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent