BDBM349945 (S)-5-(4-(2-(4-chlorobenzyl)-4-tosylpiperazin-1-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine ::US10208020, Example 35

SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN([C@@H](Cc2ccc(Cl)cc2)C1)C1CCN(CC1)c1nnc(N)[nH]1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349945   

TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349945((S)-5-(4-(2-(4-chlorobenzyl)-4-tosylpiperazin-1-yl...)
Affinity DataIC50:  5.50E+4nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349945((S)-5-(4-(2-(4-chlorobenzyl)-4-tosylpiperazin-1-yl...)
Affinity DataIC50:  5.50E+3nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent