BDBM349951 2-((2S,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)-2-methylpiperazin-1-yl)acetic acid ::US10208020, Example 41

SMILES C[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CN1CC(O)=O)C1CCN(CC1)c1nnc(N)[nH]1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349951   

TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349951(2-((2S,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)pip...)
Affinity DataIC50:  550nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

US Patent
LigandPNGBDBM349951(2-((2S,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)pip...)
Affinity DataIC50: <100nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent