BDBM350108 N-(3-(1H-1,2,4-triazol-3- ylthio)-4- hydroxynaphthalen-1- yl)-4- ethoxybenzenesulfonamide::US10208043, # 9::US10941146, # 9

SMILES CCOc1ccc(cc1)S(=O)(=O)Nc1cc(Sc2nc[nH]n2)c(O)c2ccccc12

InChI Key InChIKey=NVOQWFABHCSZFK-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350108   

TargetFascin(Homo sapiens (human))
Cornell University

US Patent
LigandPNGBDBM350108(N-(3-(1H-1,2,4-triazol-3- ylthio)-4- hydroxynaphth...)
Affinity DataIC50:  1.47E+3nMAssay Description:About 150,000 compounds were screened. These chemical compounds were from the LOPAC 1280 collection, the Prestwick chemical library, the Pharmakon co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFascin(Homo sapiens (human))
Cornell University

US Patent
LigandPNGBDBM350108(N-(3-(1H-1,2,4-triazol-3- ylthio)-4- hydroxynaphth...)
Affinity DataIC50:  1.47E+3nMAssay Description:A high throughput assay was developed to screen for fascin specific inhibitors. Purified polymerized F-actin with or without fascin were mixed and in...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM350108(N-(3-(1H-1,2,4-triazol-3- ylthio)-4- hydroxynaphth...)
Affinity DataKd:  3.10E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed