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BDBM352106 (3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(hydroxymethyl)phenyl]-5-fluoropyridin-2-yl}methyl)amino]pyridin-4-yl}-5-methylpiperidin-4-ol::US9802918, Example 35

SMILES: C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CO)cc1F

InChI Key: InChIKey=DFBNKEHODDQNEY-XMFXQIMHSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352106   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352106
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(hydr...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CO)cc1F
Show InChI InChI=1S/C24H26F3N5O2/c1-13-10-32(11-19(28)24(13)34)21-4-5-29-9-20(21)30-8-15-2-3-16(25)23(31-15)22-17(26)6-14(12-33)7-18(22)27/h2-7,9,13,19,24,30,33-34H,8,10-12,28H2,1H3/t13-,19+,24+/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352106
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(hydr...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CO)cc1F
Show InChI InChI=1S/C24H26F3N5O2/c1-13-10-32(11-19(28)24(13)34)21-4-5-29-9-20(21)30-8-15-2-3-16(25)23(31-15)22-17(26)6-14(12-33)7-18(22)27/h2-7,9,13,19,24,30,33-34H,8,10-12,28H2,1H3/t13-,19+,24+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352106
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(hydr...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CO)cc1F
Show InChI InChI=1S/C24H26F3N5O2/c1-13-10-32(11-19(28)24(13)34)21-4-5-29-9-20(21)30-8-15-2-3-16(25)23(31-15)22-17(26)6-14(12-33)7-18(22)27/h2-7,9,13,19,24,30,33-34H,8,10-12,28H2,1H3/t13-,19+,24+/m0/s1
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair