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BDBM352120 4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(2,6-difluoro-4-((methylamino)methyl)phenyl)-5-fluoropyridin-2-yl)methyl)pyridin-3-amine::US9802918, Example 49

SMILES: CNCc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F

InChI Key: InChIKey=SEXDRXMISBXRDR-XELGSYHNNA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352120   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352120
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1/C25H29F3N6/c1-15-7-17(29)14-34(13-15)23-5-6-31-12-22(23)32-11-18-3-4-19(26)25(33-18)24-20(27)8-16(10-30-2)9-21(24)28/h3-6,8-9,12,15,17,30,32H,7,10-11,13-14,29H2,1-2H3/t15-,17+/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352120
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1/C25H29F3N6/c1-15-7-17(29)14-34(13-15)23-5-6-31-12-22(23)32-11-18-3-4-19(26)25(33-18)24-20(27)8-16(10-30-2)9-21(24)28/h3-6,8-9,12,15,17,30,32H,7,10-11,13-14,29H2,1-2H3/t15-,17+/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352120
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((6-(...)
Show SMILES CNCc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1/C25H29F3N6/c1-15-7-17(29)14-34(13-15)23-5-6-31-12-22(23)32-11-18-3-4-19(26)25(33-18)24-20(27)8-16(10-30-2)9-21(24)28/h3-6,8-9,12,15,17,30,32H,7,10-11,13-14,29H2,1-2H3/t15-,17+/s2
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 550n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair