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BDBM352123 (S)-1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyridin-3-ylamino)methyl)-3-fluoropyridin-2-yl)-3,5-difluorobenzyl)pyrrolidin-3-ol::US9802918, Example 52

SMILES: C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@H](O)C2)cc1F

InChI Key: InChIKey=JYZINOSTEKDSMT-LMNJBCLMSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352123   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM352123
PNG
((S)-1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@H](O)C2)cc1F
Show InChI InChI=1S/C28H33F3N6O/c1-17-8-19(32)15-37(13-17)26-4-6-33-12-25(26)34-11-20-2-3-22(29)28(35-20)27-23(30)9-18(10-24(27)31)14-36-7-5-21(38)16-36/h2-4,6,9-10,12,17,19,21,34,38H,5,7-8,11,13-16,32H2,1H3/t17-,19+,21+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352123
PNG
((S)-1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@H](O)C2)cc1F
Show InChI InChI=1S/C28H33F3N6O/c1-17-8-19(32)15-37(13-17)26-4-6-33-12-25(26)34-11-20-2-3-22(29)28(35-20)27-23(30)9-18(10-24(27)31)14-36-7-5-21(38)16-36/h2-4,6,9-10,12,17,19,21,34,38H,5,7-8,11,13-16,32H2,1H3/t17-,19+,21+/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM352123
PNG
((S)-1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@H](O)C2)cc1F
Show InChI InChI=1S/C28H33F3N6O/c1-17-8-19(32)15-37(13-17)26-4-6-33-12-25(26)34-11-20-2-3-22(29)28(35-20)27-23(30)9-18(10-24(27)31)14-36-7-5-21(38)16-36/h2-4,6,9-10,12,17,19,21,34,38H,5,7-8,11,13-16,32H2,1H3/t17-,19+,21+/m1/s1
PDB
MMDB

KEGG

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair