BDBM352725 US10745364, Example 49::US9809561, 49::tert-butyl (2-(cyanomethyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)carbamate

SMILES CC(C)(C)OC(=O)Nc1ccc2OC(CC#N)CN(c2c1)S(=O)(=O)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=GTWAKCHBAJXRGM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352725   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352725(US10745364, Example 49 | US9809561, 49 | tert-buty...)
Affinity DataIC50:  2.46nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352725(US10745364, Example 49 | US9809561, 49 | tert-buty...)
Affinity DataIC50:  2.46nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352725(US10745364, Example 49 | US9809561, 49 | tert-buty...)
Affinity DataIC50:  2.46nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent