BDBM354301 1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)-1H-pyrazol-5-yl)-3-(4-((2-(phenylthio)-pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 29

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Sc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(cc1)P(C)(C)=O

InChI Key InChIKey=XIRXBUVFNCMKRG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 354301   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM354301(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50:  149nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determining the leve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM354301(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3?? enzyme isoform (Invitrogen), are evaluated by determining the level of ac...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM354301(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM354301(1-(3-(tert-Butyl)-1-(4-(dimethylphosphoryl)phenyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent