BDBM354527 2-(3-((4-(4- fluorophenyl) thiazol-2- yl)(methyl)amino)- 6-(1- (methylsulfonyl)- 1,2,3,6- tetrahydropyridin- 4-yl)imidazo[1,2- b]pyridazin-2- yl)acetonitrile::US9796719, Compound 196

SMILES CN(c1nc(cs1)-c1ccc(F)cc1)c1c(CC#N)nc2ccc(nn12)C1=CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=AZHXFWBHJVPRCP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354527   

LigandPNGBDBM354527(2-(3-((4-(4- fluorophenyl) thiazol-2- yl)(methyl)a...)
Affinity DataIC50:  55nMAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM354527(2-(3-((4-(4- fluorophenyl) thiazol-2- yl)(methyl)a...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent