BDBM354791 1-(4-methoxyphenyl)-6- (3,4,5-trimethoxyphenyl)- 1H-imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 68::US9814704, Example 68

SMILES COc1ccc(cc1)-n1c2nc(cnc2[nH]c1=O)-c1cc(OC)c(OC)c(OC)c1

InChI Key InChIKey=IXOSDXVNAIFVQU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354791   

TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University Of Rochester

US Patent
LigandPNGBDBM354791(1-(4-methoxyphenyl)-6- (3,4,5-trimethoxyphenyl)- 1...)
Affinity DataIC50:  550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
The University Of Rochester

US Patent
LigandPNGBDBM354791(1-(4-methoxyphenyl)-6- (3,4,5-trimethoxyphenyl)- 1...)
Affinity DataIC50:  550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent