BDBM355424 2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]-2- methylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US9815796, Example 515

SMILES COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@H](C(C)C)c2ccc(OC(F)(F)F)c(F)c2)cc1F

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355424   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355424(2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...)
Affinity DataKi:  1nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM355424(2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-...)
Affinity DataKi:  1.10nMAssay Description:In a typical experiment the PDE2 inhibitory activity of the compounds of the present invention was determined in accordance with the following experi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent