BDBM35587 pyrazolo pyrimidine, 19
SMILES COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1
InChI Key InChIKey=IMXHGCRIEAKIBU-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 35587
Affinity DataIC50: 4.30nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Wyeth Research
Wyeth Research
Affinity DataIC50: 1.03E+3nMT: 2°CAssay Description:Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. More data for this Ligand-Target Pair
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant mTOR assessed as inhibition of S6K T389 phosphorylation by DELFIA assayMore data for this Ligand-Target Pair
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Sanofi-Aventis
Curated by ChEMBL
Sanofi-Aventis
Curated by ChEMBL
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of p100alphaMore data for this Ligand-Target Pair