BDBM355879 (S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)-3-(1-methyl-2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-3-yl)urea::US10442808, Example 3::US9815842, Example 3

SMILES CO[C@@H](C)c1c(NC(=O)Nc2cc(cn(C)c2=O)C(F)(F)F)cnc2cc(Cl)nn12

InChI Key InChIKey=HORYUIPQDXGVSM-QMMMGPOBSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355879   

LigandPNGBDBM355879((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Affinity DataIC50:  0.0140nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM355879((S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]p...)
Affinity DataIC50:  0.0140nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent