BDBM355956 1-(2-chloro-7-(2- (tetrahydro-2H- pyran-4-yl)propan-2- yl)pyrazolo[1,5- a]pyrimidin-6-yl)-3- (2- (trifluoromethyl)pyri- din-4-yl)urea::US10442808, Example 80::US9815842, Example 80
SMILES CC(C)(C1CCOCC1)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12
InChI Key InChIKey=PTPDVFDUHCJQLR-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 355956
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1 [329-824](Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.0340nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 0.0340nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair