BDBM355993 1-(4-(4-(aminomethyl)-1H-pyrazol-1-yl)-3-chlorophenyl)-3-(2-chloro-7-isopropylpyrazolo[1,5-a]pyrimidin-6-yl)urea::US10442808, Example 117::US9815842, Example 117

SMILES CC(C)c1c(NC(=O)Nc2ccc(c(Cl)c2)-n2cc(CNC(=O)OC(C)(C)C)cn2)cnc2cc(Cl)nn12

InChI Key InChIKey=IBHMTOFFVPMQSR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 355993   

LigandPNGBDBM355993(1-(4-(4-(aminomethyl)-1H-pyrazol-1-yl)-3-chlorophe...)
Affinity DataIC50:  0.00800nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM355993(1-(4-(4-(aminomethyl)-1H-pyrazol-1-yl)-3-chlorophe...)
Affinity DataIC50:  0.00800nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent