BDBM357270 2-(((1s,4s)-4-((5- (methylthio)-4-(5- methylthiophen-2-yl)-3- phenyl-1H-pyrazol-1- yl)methyl)cyclohexyl) methoxy)acetic acid::US10214518, Compound 111::US11098034, Compound 111

SMILES CSc1c(-c2ccc(C)s2)c(nn1C[C@@H]1CC[C@H](COCC(O)=O)CC1)-c1ccccc1

InChI Key InChIKey=ZMROZIDRJCRQLR-KDURUIRLSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357270   

TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(2-(((1s,4s)-4-((5- (methylthio)-4-(5- methylthioph...)
Affinity DataEC50:  16nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstacyclin receptor(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(2-(((1s,4s)-4-((5- (methylthio)-4-(5- methylthioph...)
Affinity DataEC50:  16nMAssay Description:Principle of the assay: The HTRF® assay kit was purchased from Cisbio-US, Inc. (Bedford, Mass.; Catalog #62AM4PEC). The HTRF® assay supported by the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMajor prion protein(Homo sapiens (Human))
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(2-(((1s,4s)-4-((5- (methylthio)-4-(5- methylthioph...)
Affinity DataIC50:  28nMAssay Description:Blood collected from healthy human volunteers in aqueous trisodium citrate solution was centrifuged at 150 g for 15 min and the upper layer was recov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent