BDBM357654 7-(3- (trifluorometh- yl)benzyl)-3H- [1,2,3]triazolo [4,5-b]pyridin- 5-amine::US10214527, Example 26

SMILES Nc1cc(Cc2cccc(c2)C(F)(F)F)c2nn[nH]c2n1

InChI Key InChIKey=OULGOWJVPMGCES-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357654   

TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357654(7-(3- (trifluorometh- yl)benzyl)-3H- [1,2,3]triazo...)
Affinity DataIC50:  5.50E+3nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog # A12222) which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357654(7-(3- (trifluorometh- yl)benzyl)-3H- [1,2,3]triazo...)
Affinity DataIC50:  1.43E+3nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins by amplex red dye based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357654(7-(3- (trifluorometh- yl)benzyl)-3H- [1,2,3]triazo...)
Affinity DataIC50:  683nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 240 mM NaCl and 10 uM H2O2 by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed