BDBM357662 7-(3,4- difluorobenzyl)- 3H-[1,2,3] triazolo[4,5- b]pyridin-5- amine::US10214527, Example 34

SMILES Nc1cc(Cc2ccc(F)c(F)c2)c2nn[nH]c2n1

InChI Key InChIKey=MZMMOTHVEGXZFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357662   

TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357662(7-(3,4- difluorobenzyl)- 3H-[1,2,3] triazolo[4,5- ...)
Affinity DataIC50:  500nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog # A12222) which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357662(7-(3,4- difluorobenzyl)- 3H-[1,2,3] triazolo[4,5- ...)
Affinity DataIC50:  500nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen catal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent