BDBM357739 AG-01-128/(I-202)::US10214530, Example 18
SMILES CCn1c2nc(Cc3nc4ccccc4[nH]3)n(Cc3ccccc3)c2c(=O)[nH]c1=O
InChI Key InChIKey=KRRLVHYAVVYHJV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 357739
Affinity DataIC50: 430nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH2 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of N-terminal MBP-tagged full length human TPH1 assessed as reduction in 5-HTP formation incubated for 5 to 10 mins by fluorescence microp...More data for this Ligand-Target Pair
TargetTryptophan 5-hydroxylase 2(Human)
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:These compounds according to the afore-mentioned examples were tested for tryptophan hydroxylase (TPH) inhibitory activity in a fluorescence-based in...More data for this Ligand-Target Pair