BDBM357905 2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid::US10214536, Compound 246

SMILES CC(C)Cc1ccc2oc3nc(N)c(cc3c(=O)c2c1)C(O)=O

InChI Key InChIKey=DGVDZGOAEAJWPC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 357905   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM357905(2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridin...)
Affinity DataIC50:  1.23E+3nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM357905(2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridin...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents Of The University Of Michigan

US Patent
LigandPNGBDBM357905(2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridin...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM357905(2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridin...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM357905(2-Amino-7-isobutyl-5-oxo-5H-chromeno[2,3-b]pyridin...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed