BDBM358903 (6R,8aS)-6-(8-amino-1- {2-methoxy-4-[(1S)- 2,2,2-trifluoro-1- hydroxy-1- phenylethyl]phenyl} imidazo[1,5-a]pyrazin-3- yl)hexahydroindolizin- 3(2H)-one::US10214546, Example 34

SMILES COc1cc(ccc1-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12)C(O)(c1ccccc1)C(F)(F)F

InChI Key InChIKey=GBYVZSVHGHPHSN-IEYUPOKRSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358903   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM358903((6R,8aS)-6-(8-amino-1- {2-methoxy-4-[(1S)- 2,2,2-t...)
Affinity DataIC50:  0.740nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent