BDBM359546 4-[(6R or S)-6-[(3- azetidin-1- yl)pyrrolidin-1- yl)carbonyl]-1-({2- chloro-6-[1- (trifluoromethyl)cyclo propyl]phenyl}car- bonyl)-4,5,6,7- tetrahydro-1H- indazol-3-yl]-3- fluorobenzoic acid::US10221142, Example 21L

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3(CC3)C(F)(F)F)c3CC(CCc23)C(=O)N2CCC(C2)N2CCC2)c(F)c1

InChI Key InChIKey=MTLSFWKIJVFCFO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359546   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359546(4-[(6R or S)-6-[(3- azetidin-1- yl)pyrrolidin-1- y...)
Affinity DataIC50:  1.30nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent