BDBM360587 (cis)-N-((5-(3-methoxyphenyl) isoquinolin-8-yl)methyl)-2-(4- (trifluoromethyl)phenyl) cyclopropanecarboxamide (mixture of 2 isomers)::US9828369, Example 144

SMILES COc1cccc(c1)-c1ccc(CNC(=O)[C@@H]2C[C@@H]2c2ccc(cc2)C(F)(F)F)c2cnccc12

InChI Key InChIKey=JBRXIYFBQUJCJA-JWQCQUIFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 360587   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Merck Sharpe & Dohme

US Patent
LigandPNGBDBM360587((cis)-N-((5-(3-methoxyphenyl) isoquinolin-8-yl)met...)
Affinity DataIC50:  2.56E+3nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent