BDBM361068 (R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-(1H-1,2,4-triazol-3- yl)-[1,1'-biphenyl]-3,4-disulfonamide::US10221163, Example 225::US10544130, Example 225

SMILES NS(=O)(=O)c1c(ccc(-c2cccc(c2)-c2nc[nH]n2)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key InChIKey=QHJWADHROHWYDE-CYBMUJFWSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 361068   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50:  0.110nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50:  0.0260nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase()
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50:  0.0560nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50:  0.110nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50:  0.0260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM361068((R)-N4-(pyrrolidin-3-yl)-2-(2H- tetrazol-5-yl)-3'-...)
Affinity DataIC50:  0.0560nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent