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BDBM361348 (6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) benzo[d]isothiazol-3-yl) (4,4-difluoropiperidin-1-yl) methanone::US10221172, Example 5

SMILES: FC1(F)CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=MXGSKOMLNVUMSY-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361348   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361348
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) benzo[...)
Show SMILES FC1(F)CCN(CC1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C19H16F2N6OS/c20-19(21)5-8-27(9-6-19)18(28)15-12-4-3-11(10-14(12)29-26-15)23-17-16-13(24-25-17)2-1-7-22-16/h1-4,7,10H,5-6,8-9H2,(H2,23,24,25)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 60n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair