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BDBM361354 (6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[d] isothiazol- 3-yl)(2-(pyridin-2-yl) pyrrolidin-1-yl) methanone::US10221172, Example 11

SMILES: O=C(N1CCCC1c1ccccn1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key: InChIKey=LDURVZIZEHVDJL-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361354   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361354
PNG
((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Show SMILES O=C(N1CCCC1c1ccccn1)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12
Show InChI InChI=1S/C23H19N7OS/c31-23(30-12-4-7-18(30)16-5-1-2-10-24-16)20-15-9-8-14(13-19(15)32-29-20)26-22-21-17(27-28-22)6-3-11-25-21/h1-3,5-6,8-11,13,18H,4,7,12H2,(H2,26,27,28)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair