BDBM361361 (6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[d] isothiazol-3-yl)(3,5- dimethylpiperidin-1-yl) methanone::US10221172, Example 18

SMILES CC1CC(C)CN(C1)C(=O)c1nsc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 361361   

TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

US Patent
LigandPNGBDBM361361((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  517nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

US Patent
LigandPNGBDBM361361((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  447nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Vanderbilt University

US Patent
LigandPNGBDBM361361((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  447nMAssay Description:Positive allosteric modulation of human mGlu4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in glutamate-induced calcium mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed