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BDBM361367 3-propyl-N-(1H- pyrazolo[3,4-b] pyrazine-3- yl)benzo[d]isothiazol- 6-amine::US10221172, Example 24

SMILES: CCCc1nsc2cc(Nc3n[nH]c4nccnc34)ccc12

InChI Key: InChIKey=BTJCRCHYQGZMJR-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361367   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361367
PNG
(3-propyl-N-(1H- pyrazolo[3,4-b] pyrazine-3- yl)ben...)
Show SMILES CCCc1nsc2cc(Nc3n[nH]c4nccnc34)ccc12
Show InChI InChI=1S/C15H14N6S/c1-2-3-11-10-5-4-9(8-12(10)22-21-11)18-15-13-14(19-20-15)17-7-6-16-13/h4-8H,2-3H2,1H3,(H2,17,18,19,20)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 23.4n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair