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BDBM361383 3-ethyl-N-(1H- pyrazolo[4,3-b] pyridin-3- yl)isothiazolo [4,5-b]pyridin-6- amine::US10221172, Example 41

SMILES: CCc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12

InChI Key: InChIKey=ICJRXIDYPMXLFH-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361383   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361383
PNG
(3-ethyl-N-(1H- pyrazolo[4,3-b] pyridin-3- yl)isoth...)
Show SMILES CCc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C14H12N6S/c1-2-9-12-11(21-20-9)6-8(7-16-12)17-14-13-10(18-19-14)4-3-5-15-13/h3-7H,2H2,1H3,(H2,17,18,19)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 38.3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair