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BDBM361389 (6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) isothiazolo[4,5-b] pyridin-3- yl)methanol::US10221172, Example 47

SMILES: OCc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12

InChI Key: InChIKey=CVYJRHHGHPQGFA-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361389   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361389
PNG
((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) isothi...)
Show SMILES OCc1nsc2cc(Nc3n[nH]c4cccnc34)cnc12
Show InChI InChI=1S/C13H10N6OS/c20-6-9-11-10(21-19-9)4-7(5-15-11)16-13-12-8(17-18-13)2-1-3-14-12/h1-5,20H,6H2,(H2,16,17,18)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 1.07E+3n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair