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BDBM361392 3-((4,4-difluoropiperidin- 1-yl)methyl)-N- (1H-pyrazolo[4,3-b] pyridin-3-yl) isothiazolo[4,5-b]pyridin- 6-amine::US10221172, Example 50

SMILES: FC1(F)CCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CC1

InChI Key: InChIKey=ZCVXATCZSYONPB-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361392   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361392
PNG
(3-((4,4-difluoropiperidin- 1-yl)methyl)-N- (1H-pyr...)
Show SMILES FC1(F)CCN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CC1
Show InChI InChI=1S/C18H17F2N7S/c19-18(20)3-6-27(7-4-18)10-13-15-14(28-26-13)8-11(9-22-15)23-17-16-12(24-25-17)2-1-5-21-16/h1-2,5,8-9H,3-4,6-7,10H2,(H2,23,24,25)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 81.1n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair