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BDBM361402 3-((2,2- dimethylmorpholino) methyl)-N- (1H-pyrazolo[4,3-b] pyridin-3-yl)benzo [d]isothiazol-6-amine::US10221172, Example 60

SMILES: CC1(C)CN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CCO1

InChI Key: InChIKey=HFEJMVJUCJHRAV-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 361402   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM361402
PNG
(3-((2,2- dimethylmorpholino) methyl)-N- (1H-pyrazo...)
Show SMILES CC1(C)CN(Cc2nsc3cc(Nc4n[nH]c5cccnc45)cnc23)CCO1
Show InChI InChI=1S/C19H21N7OS/c1-19(2)11-26(6-7-27-19)10-14-16-15(28-25-14)8-12(9-21-16)22-18-17-13(23-24-18)4-3-5-20-17/h3-5,8-9H,6-7,10-11H2,1-2H3,(H2,22,23,24)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/an/an/a 147n/an/an/an/a



Vanderbilt University

US Patent


Assay Description
In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...


US Patent US10221172 (2019)


Article DOI: 10.1021/jm070728r
More data for this
Ligand-Target Pair