BDBM362398 4-(7-amino-3-{(3R)-1-[(1- hydroxycyclopropyl) carbonyl]piperidin-3-yl}- 1H-pyrazolo[3,4-c]pyridin-1-yl)- N-[4-(trifluoromethyl)pyridin- 2-yl]benzamide::US9834554, Example 25

SMILES Nc1nccc2c(nn(-c3ccc(cc3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CCCN(C1)C(=O)C1(O)CC1

InChI Key InChIKey=FPMUDVJXICFFLM-QGZVFWFLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 362398   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362398(4-(7-amino-3-{(3R)-1-[(1- hydroxycyclopropyl) carb...)
Affinity DataIC50:  0.590nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent