BDBM362451 (E)-N-(3-(3-(3,5-difluoro-2- methoxyphenyl)-1H-pyrrolo[2,3- b]pyridin-5-yl)-5-fluoro-2- methylphenyl)-4- (dimethylamino)but-2-enamide::US9834551, Example 169

SMILES COc1c(F)cc(F)cc1-c1c[nH]c2ncc(cc12)-c1cc(F)cc(NC(=O)\C=C\CN(C)C)c1C

InChI Key InChIKey=QEWUOLFBZCBFQH-AATRIKPKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 362451   

TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM362451((E)-N-(3-(3-(3,5-difluoro-2- methoxyphenyl)-1H-pyr...)
Affinity DataIC50: <100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM362451((E)-N-(3-(3-(3,5-difluoro-2- methoxyphenyl)-1H-pyr...)
Affinity DataIC50: <100nMAssay Description:ITK and JAK3 Kinase assay procedures:Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent